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ATTO488-ProTx-I ATTO488-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a)

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  • 产品名称:ATTO488-ProTx-I ATTO488-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a)
  • 产品型号:PTF003
  • 产品展商:其他品牌
  • 产品文档:无相关文档
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产品描述
ATTO488-ProTx-I ATTO488-ProTx-I (Protoxin 1; β-theraphotoxin-Tp1a) is a fluorescently labeled ProTx-I that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8 (IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2. ProTx-I is also an antagonist of TRAP1.
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