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GsAF-2 Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7

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  • 产品名称:GsAF-2 Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7
  • 产品型号:12GSF002-00100
  • 产品展商:其他品牌
  • 产品文档:无相关文档
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产品描述
GsAF-2 Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7 GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 µM. This peptide also blocks hERG1 with an IC50 value of 4.7 µM.
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