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Hainantoxin-IV Potent blocker of voltage-gated sodium channels

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  • 产品名称:Hainantoxin-IV Potent blocker of voltage-gated sodium channels
  • 产品型号:12HTX001-00100
  • 产品展商:其他品牌
  • 产品文档:无相关文档
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Hainantoxin-IV Potent blocker of voltage-gated sodium channels Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spider Ornithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with an IC50value of 34 nM in ***** rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.
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