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Huwentoxin-I Huwentoxin-I, blocker of N-type Ca2+ channel and TTX-S channels

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  • 产品名称:Huwentoxin-I Huwentoxin-I, blocker of N-type Ca2+ channel and TTX-S channels
  • 产品型号:07HWT001-00100
  • 产品展商:其他品牌
  • 产品文档:无相关文档
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Huwentoxin-I Huwentoxin-I, blocker of N-type Ca2+ channel and TTX-S channels Huwentoxin-I (HwTx-I) is a neurotoxin that was originally isolated from the venom of the Chinese bird spider Ornithoctonus huwena. Huwentoxin-I is known to be an inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels (TTX-S) (IC50 ~ 50 nM) and N-type voltage-sensitive calcium channels (IC50 ~ 100 nM) in mammalian DRG, hippocampus and insect’s DUM neurons. It has only a very weak effect on L-type calcium channels, no effect on TTX-R channels and has virtually no effect on muscle sodium channels. The selectivity of Huwentoxin-I for calcium channels appears to be higher than ω-conotoxin MVIIA and equivalent to ω-conotoxin GVIA. Huwentoxin-I demonstrated an antinociceptive effect in the rat model of the formalin test when administrated intrathecally (ED50 ~ 0.28 µg/kg), without side effects of the ones led by ω-conotoxin MVIIA.
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