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Phrixotoxin-3 Selective blocker of Nav1.2

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  • 产品名称:Phrixotoxin-3 Selective blocker of Nav1.2
  • 产品型号:13PHX003-00100
  • 产品展商:其他品牌
  • 产品文档:无相关文档
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产品描述
Phrixotoxin-3 Selective blocker of Nav1.2 Phrixotoxin-3 (PaurTx3 or Beta-theraphotoxin-Ps1a) is a valuable pharmacological tool to study voltage-gated sodium channels. Phrixotoxin-3, originally issued from the venom of the tarantula phrixotrichus auratus, has been shown to inhibit Nav1.1, Nav1.2, Nav1.3, Nav1.4 and Nav1.5 with respective IC50 values of 610 nM, 0.6 nM, 42 nM, 288 nM and 72 nM. It is thus considered as one of the most potent and almost selective modulator of Nav1.2.
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