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ProTx-I Blocker of voltage-gated sodium channels and T-type Cav

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  • 产品名称:ProTx-I Blocker of voltage-gated sodium channels and T-type Cav
  • 产品型号:12PTX001-00100
  • 产品展商:其他品牌
  • 产品文档:无相关文档
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产品描述
ProTx-I Blocker of voltage-gated sodium channels and T-type Cav Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8(IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2
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