产品目录
  • 联系人 : smartox-biotech
  • 联系电话 : 400-968-7988
  • 移动电话 : 18916001693
  • 地址 : 上海市闵行区新源路1356弄1-7号C801
  • Email : fuwu@bioleaf.com
  • 邮编 : 201108
  • 公司网址 : https://www.bioleaf.com
  • QQ : 800050007
产品详情
  • 产品名称:ProTx-I Blocker of voltage-gated sodium channels and T-type Cav

  • 产品型号:12PTX001-00100
  • 产品厂商:
  • 产品价格:0
  • 折扣价格:0
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详情介绍:
ProTx-I Blocker of voltage-gated sodium channels and T-type Cav Protoxin I (ProTx-I; β-theraphotoxin-Tp1a) is a toxin that was originally isolated from the venom of Thrixopelma pruriens (Peruvian green velvet tarantula). This toxin reversibly inhibits the tetrodotoxin (TTX)-resistant channel Nav1.8(IC50 = 27 nM) and Nav1.2, Nav1.5 and Nav1.7 with IC50 values between 50 and 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of T-type Cav3.1 channels (IC50= 50 nM) without affecting the voltage dependence of inactivation. ProTx-I is a valuable tool to discriminate between Cav3.1 and Cav3.2
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