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ProTx-II-Biotin ProTx-II-Biotin, a selective blocker of Nav1.7

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  • 产品名称:ProTx-II-Biotin ProTx-II-Biotin, a selective blocker of Nav1.7
  • 产品型号:12PTB002-00100
  • 产品展商:其他品牌
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ProTx-II-Biotin ProTx-II-Biotin, a selective blocker of Nav1.7 ProTx-II (Protoxin-II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula).ProTx-II inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant channels. ProTx-II inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. ProTx-II potently inhibits all sodium channel subtypes tested (Nav1.2/SCN2A, Nav1.5/SCN5A, Nav1.7/SCN9A, and Nav1.8/SCN10A). It is approximately 15-fold more potent on Nav1.7/SCN9A than on Nav1.5/SCN5A channels and acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. ProTx-II also binds to phospholipids. ProTx-II, a selective inhibitor of Nav1.7 sodium channels, blocks action potential propagation in nociceptors. ProTx-II-Biotin is a N-ter biotin labeled version of the wild-type ProTx-II
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