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µ-conotoxin-CnIIIC Selective blocker of Nav1.4 channels

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  • 产品名称:µ-conotoxin-CnIIIC Selective blocker of Nav1.4 channels
  • 产品型号:CON021-00100
  • 产品展商:其他品牌
  • 产品文档:无相关文档
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µ-conotoxin-CnIIIC Selective blocker of Nav1.4 channels µ-conotoxin CnIIIC is a conopeptide that has been isolated from the venom of the marine cone snail Conus consors. µ-conotoxin CnIIIC exhibits a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM). µ-conotoxin CnIIIC also blocks Nav1.2 channels (1 µM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. µ-conotoxin CnIIIC also blocks the α3β2 nicotinic acetylcholine receptor (IC50= 450 nM) and to lesser extents the α7 and α4β2 subtypes. µ-conotoxin CnIIIC completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM).
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