Smartox Biotechnology 主营:Smartox Biotechnology授权代理商
服务电话: 021-52271579
联系我们
产品中心
所在位置:

Guangxitoxin-1E Guangxitoxin-1E, a selective blocker of Kv2.1 and Kv2.2

  • 如果您对该产品感兴趣的话,可以
  • 产品名称:Guangxitoxin-1E Guangxitoxin-1E, a selective blocker of Kv2.1 and Kv2.2
  • 产品型号:11GUA002-00050
  • 产品展商:其他品牌
  • 产品文档:无相关文档
简单介绍

产品描述
Guangxitoxin-1E Guangxitoxin-1E, a selective blocker of Kv2.1 and Kv2.2 Guangxitoxin-1E (GxTx-1E) was isolated from the venom of Chilobrachys jingzhao (Chinese earth tiger tarantula). Guangxitoxin-1E was shown to block Kv2.1/KCNB1, Kv2.2/KCNB2 and Kv4.3/KCND3 channels without significant effect on Kv1.2/KCNA2, Kv1.3/KCNA3, Kv1.5/KCNA5, Kv3.2/KCNC2, Cav1.2/CACNA1C, Cav2.2/CACNA1B, Nav1.5/SCN5A, Nav1.7/SCN9A or Nav1.8/SCN10A channels. Guangxitoxin-1E inhibits Kv2.1 with an IC50 value of 1 nM and Kv2.2 with an IC50 value of 3 nM. Block of Kv4.3 occurs at 10-20 fold higher concentrations. Guangxitoxin-1E acts as a gating modifier since it shifts the voltage-dependence of Kv2.1 K+ currents towards depolarized potentials. In pancreatic beta-cells, Guangxitoxin-1E enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations.
产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!