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Margatoxin Kv1.3 selective blocker

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  • 产品名称:Margatoxin Kv1.3 selective blocker
  • 产品型号:08MAG001-00100
  • 产品展商:其他品牌
  • 产品文档:无相关文档
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产品描述
Margatoxin Kv1.3 selective blocker Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1.3 with an IC50 value around 50 pM (20 fold more potent than Charybdotoxin) and irreversibly inhibits the proliferation response of human T-cells at 20 µM concentration. Margatoxin is known to be less potent on Kv1.3 expressed in Xenopus Oocytes (IC50 around 1 nM). Margatoxin was also described to be a potent inhibitor of human vascular smooth muscle cell migration with an IC50 of 85 pM.
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