Smartox Biotechnology 主营:Smartox Biotechnology授权代理商
服务电话: 021-52271579
联系我们
产品中心
所在位置:

ω-agatoxin-IVA Blocker of P/Q-type calcium channel (Cav2.1)

  • 如果您对该产品感兴趣的话,可以
  • 产品名称:ω-agatoxin-IVA Blocker of P/Q-type calcium channel (Cav2.1)
  • 产品型号:11AGA001-00100
  • 产品展商:其他品牌
  • 产品文档:无相关文档
简单介绍

产品描述
ω-agatoxin-IVA Blocker of P/Q-type calcium channel (Cav2.1) ω-agatoxin-IVA (ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Cav2.1). It has been reported that ω-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for ω-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the α-1A Ca2+ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.
产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!