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  • 联系人 : smartox-biotech
  • 联系电话 : 400-968-7988
  • 移动电话 : 18916001693
  • 地址 : 上海市闵行区新源路1356弄1-7号C801
  • Email : fuwu@bioleaf.com
  • 邮编 : 201108
  • 公司网址 : https://www.bioleaf.com
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产品详情
  • 产品名称:Chlorotoxin Selective blocker of small conductance chloride channels

  • 产品型号:08CHL001-00100
  • 产品厂商:
  • 产品价格:0
  • 折扣价格:0
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Chlorotoxin Selective blocker of small conductance chloride channels Chlorotoxin (Cltx) is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin is a specific ligand of glioma cells. Chlorotoxin binds to Cl– channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl– influx. Chlorotoxin most probably acts as a specific blocker, although residues both inside and outside of the pore region of the Cl– channels participate in chlorotoxin binding. It was demonstrated that chlorotoxin inhibits specifically the activity of matrix metalloproteinase-2 (MMP-2) without affecting MMP-1, MMP-3 and MMP-9. MMP-2 are upregulated in glioma cells and related cells making chlorotoxin a promising antitumoral drug and diagnosis tool.
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