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Waglerin-1 Waglerin-1 blocks muscle-type nAChRs

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  • 产品名称:Waglerin-1 Waglerin-1 blocks muscle-type nAChRs
  • 产品型号:12WAG001-01000
  • 产品展商:其他品牌
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Waglerin-1 Waglerin-1 blocks muscle-type nAChRs Waglerin-1 (Wtx-1) is a peptide originally isolated from the venom of the Wagler’s pit viper (Trimeresurus wagleri). This 22 amino-acid peptide is a competitive antagonist of muscle nicotinic acetylcholine receptors. Waglerin-1 competes with α-bungarotoxin. Waglerin-1 is an interesting tool to discriminate between fetal and ***** muscle nAChRs as it binds to the α-ε subunit interface with a ~ 2000 fold higher affinity than to the α-γ or α-δ subunits. Waglerin-1 is known to bind 100 fold more potently to nAChR from ***** mice than that from rat or humans. It blocks muscle nAChR from ***** mice with an IC50 value of 50nM. Some studies have demonstrated that Waglerin-1 has an effect on ionotropic GABA receptors. It may potentiate or depress I(GABA) depending on the neurons. Some derivatives of Waglerin-1 are currently used in cosmetics to reduce wrinkles.
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