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  • 联系人 : smartox-biotech
  • 联系电话 : 400-968-7988
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产品详情
  • 产品名称:α-conotoxin-PeIA Discriminates between α9α10 and α7 nAChRs

  • 产品型号:13CON017-00100
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  • 产品价格:0
  • 折扣价格:0
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详情介绍:
α-conotoxin-PeIA Discriminates between α9α10 and α7 nAChRs α-conotoxin PeIA is a conotoxin that has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC50 values of 7-50 nM (depending of the authors) and 1.8 µM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC50 of 97 nM) and block voltage-gated N-type Ca2+ channels in rat DRG neurons with an IC50 of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 µM α-conotoxin PeIA was observed. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.
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