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  • 联系人 : smartox-biotech
  • 联系电话 : 400-968-7988
  • 移动电话 : 18916001693
  • 地址 : 上海市闵行区新源路1356弄1-7号C801
  • Email : fuwu@bioleaf.com
  • 邮编 : 201108
  • 公司网址 : https://www.bioleaf.com
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产品详情
  • 产品名称:MitTx MitTx toxin – ASIC1a/1b agonist

  • 产品型号:MTX002
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详情介绍:
MitTx MitTx toxin – ASIC1a/1b agonist MitTx is a peptide isolated from the Venom of the Texas coral snake Micrurus tener tener. MitTx is a selective agonist for acid-sensing ion channels 1 (ASIC1s) and produces a similar effect than pH drops. MitTx activates both ASIC1a & ASIC1b with a higher selectivity for ASIC1a (EC50 = 9.4 nM) compared to the ASIC1b (EC50= 23 nM). MitTx also demonstrates an activity for ASIC3 with a lower potency (EC50=830 nM). The venom toxin MitTx is an heterodimer composed of an α subunit of ~ 7 kDa and a β subunit of ~ 13.5 kDa. These two subunits when isolated do not present activity against ASIC channels. In vivo, the heterodimer elicits a robust pain-related behavior in mice by activation of ASIC1 channels on capsaicin-sensitive nerve fibers Bio***** results obtained in patch clamp at 30nM on the rASIC1a and rASIC1b expressed in xenopus oocytes.
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