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GsMTx4 Selective blocker of mechanosensitive ion channels

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  • 产品名称:GsMTx4 Selective blocker of mechanosensitive ion channels
  • 产品型号:08GSM001-00050
  • 产品展商:其他品牌
  • 产品文档:无相关文档
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GsMTx4 Selective blocker of mechanosensitive ion channels GsMTx4 (GsMTx-4, M-theraphotoxin-Gr1a) has been isolated from the venom of the spider Grammostola rosea. This cationic hydrophobic polypeptide blocks selectively the gating of cation selective channels and mechanosensitive ion channels such as TRPC1 or TRPC6, without having any effect on whole-cell voltage-sensitive currents. This toxin acts by perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. GsMTx4 also demonstrated to active TRPA1 channel at 1µM concentration and to inhibit Piezo1 currents.
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