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ρ-Da1a – AdTx1 Selective antagonist of the alpha(1A)-adrenoceptor

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  • 产品名称:ρ-Da1a – AdTx1 Selective antagonist of the alpha(1A)-adrenoceptor
  • 产品型号:ADT001-00010
  • 产品展商:其他品牌
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ρ-Da1a – AdTx1 Selective antagonist of the alpha(1A)-adrenoceptor AdTx1 (rho-Da1a – ρ-Da1a) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep). AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K(i)= 0.35 nM) and high specificity for the human alpha(1A)-adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1 is a potent relaxant of smooth muscles.
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