产品目录
  • 联系人 : smartox-biotech
  • 联系电话 : 400-968-7988
  • 移动电话 : 18916001693
  • 地址 : 上海市闵行区新源路1356弄1-7号C801
  • Email : fuwu@bioleaf.com
  • 邮编 : 201108
  • 公司网址 : https://www.bioleaf.com
  • QQ : 800050007
产品详情
  • 产品名称:Obtustatin Inhibitor of the binding of α1β1 integrin to collagen IV

  • 产品型号:10OBT001-00100
  • 产品厂商:
  • 产品价格:0
  • 折扣价格:0
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详情介绍:
Obtustatin Inhibitor of the binding of α1β1 integrin to collagen IV Obtustatin is a 41 amino acid disintegrin peptide isolated from the venom of the Vipera lebetina obtusa. It is a potent (IC50 = 2 nM) and selective inhibitor of the binding of α1β1 integrin to collagen IV. Contrary to other known disintegrins, it does not contain the classical RGD sequence. Obtustatin does not show inhibitory activity toward other integrins, including α2β1, αIIbβ3, αvβ3, α4β1, α5β1, α6β1, and α9β1, α4β7 integrins. Obtustatin potently inhibits angiogenesis in chicken and in mouse model and reduces tumor development by half.
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