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Conantokin-G Selective inhibitor of NR2B-containing NMDAR

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  • 产品名称:Conantokin-G Selective inhibitor of NR2B-containing NMDAR
  • 产品型号:08CON009-00500
  • 产品展商:其他品牌
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Conantokin-G Selective inhibitor of NR2B-containing NMDAR Conantokin-G is a conopeptide that has been isolated from the venom of the cone Conus geographus. Conantokin-G selectively inhibits NR2B containing N-methyl-D-aspartate receptors (NMDAR) with a high specificity. Thus, Conantokin-G inhibits in a concentration-dependent manner the Ca2+ influx leading to a neuroprotective effect against NMDA-induced excitotoxicity. Conantokin-G was shown to block NMDA-evoked currents in murine cortical neurons with an IC50 value of around 480 nM.
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